Palladium-free zinc-mediated hydroamination of alkynes: efficient synthesis of indoles from 2-akynylaniline derivatives |
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Authors: | Kentaro Okuma Jun-ichi Seto Ken-ichi Sakaguchi Saori Ozaki Noriyoshi Nagahora Kosei Shioji |
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Affiliation: | Department of Chemistry, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan |
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Abstract: | Reaction of 2-phenylethynyl N-tosylanilide prepared by Pd-free procedure with ZnBr2 (3 equiv) in refluxing toluene gave N-tosyl-2-phenylindole in 93% yield. Treatment of 2-phenylethynylaniline with ZnBr2 (1 equiv) in refluxing toluene resulted in the formation of 2-phenylindole in 91% yield. Catalytic ZnBr2 (0.05 equiv) effectively reacted with 2-alkynylanilines to afford 2-substituted indoles in high yields. Thus, complete Pd-free zinc catalyzed hydroamination of 2-alkynylanilines was achieved. |
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