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An intramolecular one-pot synthesis of steroidal triazoles via 1,3-dipolar cycloadditions of in situ generated diazo compounds |
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| Authors: | Marija N Saka? Andrea R Gakovi? Evgenija A Djurendi? Vesna Koji? Katarina M Penov Gaši |
| Institution: | a Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovi?a 3, 21 000 Novi Sad, Serbia b Department of Physics, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg Dositeja Obradovi?a 4, Serbia c Oncology Institute of Vojvodina, Institutski put 4, 21204 Sremska Kamenica, Serbia |
| Abstract: | A novel synthetic route is reported for the preparation of steroidal triazoles via intramolecular 1,3-dipolar cycloaddition of a steroidal 16,17-seco-17-diazo-16-nitrile system. The structures of the products are established by X-ray and NMR studies. The in vitro antiproliferative activity of the steroidal triazoles against three tumor cell lines was evaluated. |
| Keywords: | Steroidal triazoles 1 3-Dipolar cycloaddition Nitriles Dipolarophiles In vitro cytotoxicity |
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