Labelling of peptides with 99mTc complexes through the modified C-terminal group |
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Authors: | Przemysław Koźmiński Ewa Gniazdowska Leon Fuks Agata Oszczak |
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Affiliation: | (1) Institute of Nuclear Chemistry and Technology, Warsaw, Poland |
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Abstract: | Easy and efficient way to modify of the C-terminus of the peptide using amino acid lysine has been proposed and experimentally verified. The synthesis yield was high (≥85%) and it was found that reactions can be carried out even with microgram amounts of the peptide. Using Fmoc-alanine (as the peptide model) with modified C-terminus the procedure of peptide labelling with monovalent and trivalent 99mTc complexes has been elaborated. |
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