|
|||||
|
|
A novel approach to Finafloxacin hydrochloride (BAY35-3377) |
|
| Authors: | Jian Hong Zonghua Zhang Huoxing Lei Haiying Cheng Yufang Hu Wanliang Yang Yinglin Liang Debasis Das Shu-Hui Chen Ge Li |
| Institution: | WuXi AppTec Inc., 288 Fute Zong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China |
| Abstract: | Finafloxacin hydrochloride, an important clinical compound was synthesized by a novel synthetic approach. An active intermediate ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 19 was prepared by a new route. The chiral (S,S′)-N-Boc 10 was derived from protected pyrrolidine and the absolute stereochemistry was established by X-ray analysis. |
| Keywords: | Finafloxacin hydrochloride BAY35-3377 Fluoroquinolone antibiotics |
| 本文献已被 ScienceDirect 等数据库收录！ | |