The synthesis of carbohydrate-derived acylsilanes and their intramolecular free radical cyclizations with the formation of polyoxygenated cyclopentanes |
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Authors: | Che-Chien Chang |
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Affiliation: | Department of Chemistry, National Taiwan University, Taipei, Taiwan 106, ROC |
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Abstract: | A convenient way for the synthesis of acylsilanes from arabinose, lyxose, and ribose is developed. All the chiral centers of the carbohydrate templates are conserved, and only the reducing end is transformed into the acylsilane functional group. The non-reducing end of the templates can be converted into a bromide. These bromo acylsilanes undergo efficient intramolecular radical cyclizations to give polyoxygenated cyclopentanes. |
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Keywords: | Acylsilane Radical cyclization Polyoxygenated cyclopentanes |
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