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An efficient total synthesis of (+)-Cladospolide C |
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| Authors: | Ch Raji Reddy N Narsimha Rao |
| Institution: | Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | The asymmetric synthesis of (+)-Cladospolide C has been achieved in 11 steps with 26% overall yield. Key steps in the sequence involve KAPA-promoted alkyne Zipper reaction, TPP-promoted enyne ester (ynoate) to diene ester (dienoate) isomerization, Sharpless asymmetric dihydroxylation and Yamaguchi macrolactonization. |
| Keywords: | Cladospolide Alkyne zipper reaction Ynoate isomerization Sharpless asymmetric dihydroxylation Yamaguchi macrolactonization |
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