Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones |
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| Authors: | Steven N Gallicchio Ian M Bell |
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| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA |
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| Abstract: | The convenient preparation of novel 6-phenylpiperazin-2-ones from simple starting materials via a practical two-step procedure is presented. This methodology involves an initial alkylation of 2-bromoacetophenone with an amino ester followed by a one-pot reductive amination and cyclization step to furnish the desired substituted piperazinones. |
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