Palladium-catalysed allylic amination for the direct synthesis of epi-4-alkylamino-N-acetylneuraminic acid derivatives |
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| Authors: | Ricardo Resende |
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| Institution: | Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom |
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| Abstract: | A simple and efficient procedure has been developed for the direct formation of epi-4-alkylamino-N-acetylneuraminic acid derivatives as potential inhibitors of influenza neuraminidases. The allylic amination of oxazoline 6 has been effected with a series of primary and secondary amines in the presence of catalytic Pd(π-allyl)2(Et3P)2 to give the corresponding 4-epi-alkylamino products in a stereoselective and regiospecific manner. |
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| Keywords: | Allylic amination Neuraminidase inhibitors 4-epi-Alkylamino-N-acetylneuraminic acids Palladium |
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