Preparation of a core-shell type MBHA resin and its application for solid-phase peptide synthesis |
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| Authors: | Jeong-Hyun Choi Jang-Woong Byun |
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| Institution: | a School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea
b BeadTech Inc., Institute for Chemical Processes, Seoul National University, Seoul 151-744, Republic of Korea |
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| Abstract: | MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core-shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation and partial hydrolysis. The core-shell structure of the MBHA resin was confirmed by two-photon microscopy and its synthetic performance in solid-phase peptide synthesis (SPPS) was evaluated. |
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| Keywords: | MBHA resin Core-shell-type resin α-Amidoalkylation Partial hydrolysis Solid-phase peptide synthesis |
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