| 微波法合成S-苄基半胱氨酰甘氨酸乙酯 |
| |
| 引用本文： | 徐秋霞,钦维民. 微波法合成S-苄基半胱氨酰甘氨酸乙酯[J]. 合成化学, 2009, 17(6) |
| |
| 作者姓名： | 徐秋霞 钦维民 |
| |
| 作者单位： | 东华大学,化学化工与生物工程学院,上海,201620;东华大学,化学化工与生物工程学院,上海,201620 |
| |
| 摘 要： | 微波条件下,溴化氢醋酸对S-苄基-N-苄氧羰基半胱氨酰甘氨酸乙酯(1)进行脱保护反应,合成了S-苄基半胱氨酰甘氨酸乙酯(2).最佳反应条件为:1 2.9 mmol,n(1):n(HBr-AcOH)=1:6,微波功率200 W,于30 ℃辐射20 min,2的收率为87%.其结构经~1H NMR和IR表征.
|
| 关 键 词： | 微波合成 脱保护 半胱氨酰甘氨酸 |
Synthesis of S-benzylcysteinylglycine Ethyl Ester under Microwave Irradiation |
| |
| XU Qiu-xia,QIN Wei-min. Synthesis of S-benzylcysteinylglycine Ethyl Ester under Microwave Irradiation[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(6) |
| |
| Authors: | XU Qiu-xia QIN Wei-min |
| |
| Abstract: | S-benzylcysteinylglycine ethyl ester(2) was synthesized by de-protect reaction of S-benzyl-N-benzyloxycarbonyl-cysteinylglycine ethyl ester(1) with HBr-AcOH under microwave irradiation. The structure was confirmed by ~1H NMR and IR. The optimum reaction conditions at 30 ℃ for 20 min were as follows: 1 was 2.9 mmol; n(1) :n(HBr-AcOH) was 1:6； power was 200 W. The yield of 2 was 87% under the conditions. |
| |
| Keywords: | microwave synthesis de-protection cysteinylglycine |
| 本文献已被 万方数据 等数据库收录！ |
|
