Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereomutation processes |
| |
Authors: | D'Acquarica Ilaria Gasparrini Francesco Pierini Marco Villani Claudio Zappia Giovanni |
| |
Affiliation: | Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma La Sapienza, Rome, Italy. |
| |
Abstract: | Dynamic HPLC on enantioselective stationary phases has become a well-established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time scale of the separation process. Kinetic parameters for the on-column interconversion phenomena can be extracted from experimental peak profiles by computer simulation or by direct calculation methods. The technique has been used in a wide range of temperatures and is complementary in scope to dynamic NMR spectroscopy. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |