Regioselective oxidative coupling reactions of 3-substituted thiophenes with arylboronic acids |
| |
Authors: | Schnapperelle Ingo Breitenlechner Stefan Bach Thorsten |
| |
Institution: | Lehrstuhl fu?r Organische Chemie I and Catalysis Research Center, Technische Universita?t Mu?nchen, Lichtenbergstr. 4, 85747 Garching, Germany. |
| |
Abstract: | Under optimized conditions, 3-substituted thiophenes (EWG = COOEt, PO(OEt)(2)) undergo a facile and regioselective oxidative coupling reaction at carbon atom C4. The reactions were performed with various aryl boronic acids as nucleophiles in the presence of silver oxide (2.0 equiv), cesium trifluoroacetate (tfa) (1.0 equiv), benzoquinone (BQ) (0.5 equiv), and catalytic amounts of Pd(tfa)(2) (10 mol %) employing trifluoroacetic acid (TFA) as the solvent. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|