Tandem Michael addition/ylide epoxidation for the synthesis of highly functionalized cyclohexadiene epoxide derivatives |
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| Authors: | Wang Qing-Gang Deng Xian-Ming Zhu Ben-Hu Ye Long-Wu Sun Xiu-Li Li Chuan-Ying Zhu Chun-Yin Shen Qi Tang Yong |
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| Affiliation: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 FengLin Lu, Shanghai 200032, China. |
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| Abstract: | A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields. |
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