Synthesis,characterisation and chromatographic evaluation of polyether dendrimer stationary phases |
| |
| Authors: | Gerard P O’Sullivan Norma M Scully Jean-Marie Prat Jeremy D Glennon Benjamin Dietrich Volker Friebolin Klaus Albert |
| |
| Institution: | 1.Department of Chemistry, Analytical and Biological Chemistry Research Facility (ABCRF),University College Cork,Cork,Ireland;2.Institüt für Organische Chemie,Universit?t Tübingen,Tübingen,Germany |
| |
| Abstract: | Supercritical carbon dioxide has attracted attention as a potential replacement for traditional organic solvents due to its
simplified workup procedures and reduced environmental impact—providing a green chemistry approach for organic solvent-free
functionalisation. In addition to the environmental benefits, the enhanced diffusivity observed in supercritical solvents
can often enhance reaction rates. We have applied these valuable features to the preparation of silica-bonded stationary phases
and examined their potential in liquid chromatography. We report the successful preparation and characterisation of polyether
silica based on Frechet dendrimers—this significantly enhances the range of stationary-phase chemistries that can be prepared
in supercritical fluids. First- and second-generation polyether silicas were prepared, characterised, end-capped and evaluated
for use as stationary phases for liquid chromatography.
Figure SRM1649 on 2nd generation polyether silica
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
|
| |
| Keywords: | Polyether stationary phases Frechet dendrimer Supercritical carbon dioxide Silica functionalisation |
| 本文献已被 SpringerLink 等数据库收录！ |
|
