Total synthesis of (+/-)-mycoepoxydiene,a novel fungal metabolite having an oxygen-bridged cyclooctadiene skeleton |
| |
Authors: | Takao Ken-ichi Watanabe Gohshi Yasui Hiroyuki Tadano Kin-ichi |
| |
Institution: | Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. |
| |
Abstract: | reaction: see text] The first total synthesis of (+/-)-mycoepoxydiene has been accomplished. A ring-closing olefin metathesis (RCM) approach was employed for the construction of the oxygen-bridged eight-membered bicyclic skeleton. The RCM product was converted to the target natural product featuring the oxidative rearrangement of a furfuryl alcohol introduced as the side chain and the stereoselective 1,2-reduction of a delta-keto-beta,gamma-unsaturated alpha-lactol intermediate. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|