Design synthesis and biological evaluation of 3-substituted triazole derivatives |
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| Authors: | Bao Gang Wang Shi Chong Yu Xiao Yun Chaia Yong Zheng Yana Hong Gang Hu Qiu Ye Wua a |
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| Institution: | a Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;b Pharmacy Team, Administrative Brigade of Postgraduate, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4- difluorophenyl)-3-(N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed,synthesized and evaluated as antifungal agents.Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum. |
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| Keywords: | Synthesis Triazole Antifungal activity 1 3-Dipolar cycloaddition |
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