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| Asymmetric aza-Henry reaction with α-substituted nitroacetates catalyzed by a bifunctional thiourea-guanidine catalyst | |
| 作者姓名： | Bo Han Wei Huang Zhen Rui Xu Xiao Ping Dong |
| 作者单位： | a State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;b State Key Laboratory of Oral Diseases, Department of Orthodontics, West China College of Stomatolgy, Sichuan University, Chengdu 610041, China |
| 基金项目： | the Scientific Research Fund ofSichuan Provincial Education Department(No.310-347); Technology Department of Chengdu University of TCM(Nos.310-446 and 310-448)for financial support |
| 摘 要： | The asymmetric aza-Henry reaction of α-substituted nitroacetates and N-Boc imines was achieved with a new-type thioureaguanidine bifunctional organocatalyst.The novel transformations exhibited high diastereoselectivities,and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities(up to 88%ee). |
| 关 键 词： | Aza-Henry reaction Thiourea Guanidine Nitroacetate Organocatalysis |
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