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Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity |
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| Authors: | Jing Bo Shi Song Xua Ya Ping Wangc Jing Jing Lia Qi Zheng Yao a School of Pharmacy China Pharmaceutical University Nanjing China b School of Pharmacy Anhui Medical University Hefei China c Anhui Zhaoke Pharmaceutical Co Ltd Hefei China |
| Institution: | a School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;b School of Pharmacy, Anhui Medical University, Hefei 230032, China;c Anhui Zhaoke Pharmaceutical Co., Ltd., Hefei 230088, China |
| Abstract: | New pyrimidine nucleoside derivatives with nitric oxide(NO) donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus(VSV) in Wish cell were evaluated.It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir,while their toxicities were similar or lower to acyclovir. |
| Keywords: | Pyrimidine nucleoside NO-donor Antivirus Furoxans Oximes Synthesis |
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