First total synthesis of two new heterocyclic compounds:Bretschneiderazines A and B |
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| Authors: | Qing Chao Liu Tian Tian Guob Zheng Fana Dong Lia Wen Hong Lia a |
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| Affiliation: | a Department of Pharmaceutical Engineering, Northwest University, Xi’an 710069, China;b Department of Medical Science, Xi’an Creation College, Yanan University, Xi’an 710100, China |
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| Abstract: | Facile synthesis of the two new natural heterocyclic compounds bretschneiderazines A(2) and B(3),isolated from an extract of the stems of Bretschneidera sinensis,is reported.We employed the cyclization reaction of benzamide by directed lithiation and sequential treatment with sulfur and phosgene as key steps.All new compounds have been fully characterized by means of IR,~1H NMR,~(13)C NMR,and HRMS. |
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| Keywords: | Heterocyclic compounds Bretschneiderazines Directed lithiation Synthesis |
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