A new triterpenoid saponin from the roots of Ardisia crenata |
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| Authors: | Dai Lin Liu Xue Zhangc Shu Ping Wangb Nai Li Wangc Xin Sheng Yaoc a Tianjin Key Laboratory for Biomarkers of Occupational Environmental Hazard Tianjin China b |
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| Institution: | a Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Tianjin 300162, China;b Department of Pharmacognosy, Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China;c Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | A new triterpenoid saponin.3 β-O-{ β-D-glucopyranosyl-(1—4)- β-D-glucopyranosyl-1-2)]- α-L-arabinopyranosyl}-16α, 28-dihydroxyolean-12-en-30-oic acid 30-O- β-D-glucopyranosyl ester(ardisicrenoside N.1),together with two known saponins, ardisicrenoside C(2) and D(3),were isolated from the roots of Ardisia crenata Sim.Their structures were elucidated by extensive spectral analysis and chemical evidences.Saponins 1 showed cytotoxicity against MCI-7 and NCI-H460 cancer cell lines at 11.0μmol/L and 22.1μmol/L in vitro. |
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| Keywords: | Ardisia crenata Sims Ardisicrenoside N Cytotoxicity |
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