| Crystal structure and DNA binding studies of a cobalt(Ⅱ) complex containing mixed-ligands of 1,10-phenathroline and glycollic acid |
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| 作者姓名： | Hai Bin Lin Qing Xiang Wang Cong Min Zhang Wen Qi Li |
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| 作者单位： | a Department of Chemistry and Environmental Science, Zhangzhou Normal University, Zhangzhou 363000, China;b Department of Bioscience with Technique, Zhangzhou Normal University, Zhangzhou 363000, China |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.20805041); Training Programme Foundation for Excellent Youth Researching Talents of Fujian's Universities(No.JA10201); Key Provincial University Project of Fujian(No.2008F5064); Research Foundation of Fujian Education Department (No.JA09170) |
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| 摘 要： | A cobalt（11） complex containing mixed-ligands of 1,10-phenathroline（phen） and glycollic acid（GA）.|Co（GA）2（phen）| was synthesized and its structure was characterized by X-ray diffraction.The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods.Electronic absorption spectrum experiments showed that after interaction with DNA.the characteristic absorption peaks of |Co（GA）2（phen）| underwent hypochromic effect as well as redshift. Also,the binding strength of 3.8×104L/mol was estimated by titration method.Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA.All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode.
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| 关 键 词： | Cobalt complex DNA binding Electronic absorption spectra Electrochemistry |
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