Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles(Ⅱ):From triazolothiadiazines to pyrazolotriazoles |
| |
作者姓名: | Guo Qiang Hu Li Li Hou Yong Yang Lei Yi Song Qiang Xie Guo Qiang Wang Nan Nan Duan Tie Yao Chao Xiao Yi Wen Wen Long Huang |
| |
作者单位: | a Institute of Chemistry & Biology, Henan University, Kaifeng 475001, China;b China Pharmaceutical University, Nanjing 210009, China |
| |
基金项目: | supported by National Natural Science Foundation of China(Nos.20872028,21072045) |
| |
摘 要: | To further expand an effective modified route for the shift from an antibacterial fluoroquinolone(FQ) to an antitumor FQ,two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings,[1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole,respectively,were designed and synthesized starting from the current antibacterial FQs,and their in vitro antitumor activity against L1210,CHO cell lines were evaluated via their respective IC50 values.
|
关 键 词: | Fluoroquinolone Triazolothiadiazine Pyrazolotriazole Antitumor evaluation |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
|