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Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives |
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| Authors: | Li Chen Wen Qiua Jia Tanga Zhi Feng Wangb Shu Ying He a |
| Institution: | a Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China;b Tianjin Hankang Medicinal & Biological Technology Co., Ltd., Tianjin 300203, China;c School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China |
| Abstract: | A series of furoxan-based novel nitric oxide-donating ursolic acid(UA) derivatives(7a-f) were synthesized,and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method.It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA. |
| Keywords: | Ursolic acid Nitric oxide Furoxan Cytotoxic activity |
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