| (1R,3R)-1-氨基-1,3-二羧基环丁烷衍生物桥联环糊精与一组低分子量多肽之间的包合行为 |
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| 引用本文： | 宋乐新,涂超,赵亮,郭子建.(1R,3R)-1-氨基-1,3-二羧基环丁烷衍生物桥联环糊精与一组低分子量多肽之间的包合行为[J].无机化学学报,2002,18(5):518-522. |
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| 作者姓名： | 宋乐新 涂超 赵亮 郭子建 |
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| 作者单位： | 南京大学配位化学研究所,配位化学国家重点实验室,南京 210093,南京大学配位化学研究所,配位化学国家重点实验室,南京 210093,南京大学配位化学研究所,配位化学国家重点实验室,南京 210093,南京大学配位化学研究所,配位化学国家重点实验室,南京 210093 |
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| 基金项目： | 国家自然科学基金资助项目(No.29925102) |
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| 摘 要： | The interactions between several peptides with low molecular weight (guest, NH2-Arg-Arg-Trp-Trp-H 2; NH2-Arg-Trp-Arg-Trp-H 3; NH2-Trp-Arg-Arg-Trp-H 4; NH2-Arg-Arg-Trp-Trp-Trp-Trp-H 5; NH2-Trp-Trp-Arg-Arg- Trp-Trp-H 6; NH2-Arg-Arg-Trp-Trp-Trp-Trp-Trp-Trp-H 7; NH2-Arg-Arg-Trp-Trp-Trp-Trp-Trp-Trp-Trp-Trp-H 8) and β-cyclodextrin dimer (host, 1) bridged with the derivative of (1R, 3R)-1-aminocyclobutane-cis-1,3-dicar- boxylic acid were investigated by using fluorescence polarization method in buffer aqueous solution (pH 7.4) at 298K. The binding constants of the cyclodextrin dimer 1 to the guests 2-8 were determined. It was shown that there was a cooperative action of the two cavities of a cyclodextrin dimer in the binding of large substrates, and that the structure and properties of amino acid in the peptides played very important roles in the synergic complexation between host and guest.
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| 关 键 词： | 环糊精 氨基酸 多肽 包合物 分子识别 |
| 修稿时间： | 2001年12月18 |
Inclusion Behavior of the Double Cyclodextrin Bridged with (1R,3R)-1-Amino-Cyclobutane-cis-1,3-Dicarboxylic Acid Derivative to the Peptides with Low Molecular Weight |
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| SONG Le-Xin,TU Chao,ZHAO Liang and GUO Zi-Jian.Inclusion Behavior of the Double Cyclodextrin Bridged with (1R,3R)-1-Amino-Cyclobutane-cis-1,3-Dicarboxylic Acid Derivative to the Peptides with Low Molecular Weight[J].Chinese Journal of Inorganic Chemistry,2002,18(5):518-522. |
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| Authors: | SONG Le-Xin TU Chao ZHAO Liang and GUO Zi-Jian |
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| Institution: | Coordination Chemistry and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,Coordination Chemistry and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,Coordination Chemistry and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 and Coordination Chemistry and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 |
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| Abstract: | |
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| Keywords: | cyclodextrin amino acid peptide inclusion compound molecular recognition |
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