A near-infrared fluorescent probe for detecting copper(II) with high selectivity and sensitivity and its biological imaging applications |
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| Authors: | Li Ping Duan Xia Chen Zhenzhen Liu Ying Xie Ting Fang Libo Li Xiaorui Yin Miao Tang Bo |
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| Institution: | College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, PR China. |
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| Abstract: | The first near-infrared fluorescent probe was developed toward Cu(2+). Based on the photo-induced electron transfer (PET) mechanism, the probe exhibited weak fluorescence. Upon the addition of Cu(2+), it fluoresced strongly. The probe offered this unique capability, and was successfully applied to living cells, tissues and in vivo to visualize Cu(2+). |
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