Techniques to Study Inflammasome Activation and Inhibition by Small Molecules |
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| Authors: | Diego Angosto-Bazarra Cristina Molina-Lpez Alejandro Peín-Franch Laura Hurtado-Navarro Pablo Pelegrín |
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| Institution: | Línea de Inflamación Molecular, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain; (C.M.-L.); (A.P.-F.); (L.H.-N.) |
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| Abstract: | Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules. |
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| Keywords: | inflammasomes small molecules techniques to assay inflammasome activation auto-active inflammasomes NLRP3 inhibitors |
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