| IDENTIFICATION OF PARTIAL MUTATIONAL SITES IN HUMAN MITOCHONDRIAL DNA IN THE CHINESE AND ITS SIGNIFICANCE |
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| 引用本文： | 俞民澍,邱信芳,薛京伦,刘祖洞,谈家桢,李厚钧,刘德祥,李力,余伍忠. IDENTIFICATION OF PARTIAL MUTATIONAL SITES IN HUMAN MITOCHONDRIAL DNA IN THE CHINESE AND ITS SIGNIFICANCE[J]. 中国科学B辑(英文版), 1989, 0(4) |
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| 作者姓名： | 俞民澍 邱信芳 薛京伦 刘祖洞 谈家桢 李厚钧 刘德祥 李力 余伍忠 |
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| 作者单位： | Institute of Genetics，Fudan University，Shanghai，Institute of Genetics，Fudan University，Shanghai，Institute of Genetics，Fudan University，Shanghai，Institute of Genetics，Fudan University，Shanghai，Institute of Genetics，Fudan University，Shanghai，Genetics Group，Xinjiang Urumqi General Military Hospital，Urumqi，Genetics Group，Xinjiang Urumqi General Military Hospital，Urumqi，Genetics Group，Xinjiang Urumqi General Military Hospital，Urumqi，Genetics Group，Xinjiang Urumqi General Military Hospital，Urumqi |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | A simple method for the identification of mutational sites in human mitochondrial DNA (mtDNA) was described. It was based on the human Cambridge sequence as a relative standard sequence and a single base pair substitution in mtDNA as a unique mutational form. The partial mutational sites can be determined using this method which was characterized by combining the restriction mapping with the analysis for the table of human mtDNA potential mutational sites with rapidity and simplicity. In the meanwhile, six mtDNA mutational sites found in Chinese population were identified by means of this method.
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IDENTIFICATION OF PARTIAL MUTATIONAL SITES IN HUMAN MITOCHONDRIAL DNA IN THE CHINESE AND ITS SIGNIFICANCE |
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| YU MIN-SHU QIU KIN-FANG XUE JING-LUN. IDENTIFICATION OF PARTIAL MUTATIONAL SITES IN HUMAN MITOCHONDRIAL DNA IN THE CHINESE AND ITS SIGNIFICANCE[J]. Science in China(Chemistry), 1989, 0(4) |
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| Authors: | YU MIN-SHU QIU KIN-FANG XUE JING-LUN |
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| Abstract: | A simple method for the identification of mutational sites in human mitochondrial DNA (mtDNA) was described. It was based on the human Cambridge sequence as a relative standard sequence and a single base pair substitution in mtDNA as a unique mutational form. The partial mutational sites can be determined using this method which was characterized by combining the restriction mapping with the analysis for the table of human mtDNA potential mutational sites with rapidity and simplicity. In the meanwhile, six mtDNA mutational sites found in Chinese population were identified by means of this method. |
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| Keywords: | human mitochondrial DNA mutational sites Chinese population. |
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