智能型色谱整体固定相的研究进展

整体柱作为新一代色谱固定相,具有原位制备、快速传质和高通透性的特点,近年来引起人们的极大关注。智能型聚合物作为一类功能性材料,能在温度、pH和盐等环境因素的刺激下产生特异性响应变化,通常被修饰到固相载体表面用来构造环境敏感性材料,使得该智能材料在药物控释、化学传感和细胞生长等领域有着广泛的应用。因此,在整体柱上构造智能型表面更为其在色谱领域的发展提供了新的契机。本文主要综述了近年来智能型整体柱在色谱领域的研究进展。

Development of intelligent monolithic stationary phase for chromatography

In recent years, great attention has been paid to monolith, which is developed as a new generation of chromatographic stationary phase, due to its advantages of in-situ preparation, fast mass transfer and high permeability. Besides, as a class of functional materials, intelligent polymer could response to external environmental stimuli, such as temperature, pH, salt and so on. This intelligent polymer is usually modified onto solid support surface for fabrication of environmental responsive materials, which could be widely applied in drug release, chemical sensing, cell growth, etc. As a result, the construction of intelligent surface on monolith can provide new opportunities for its development in chromatography. This review summarizes the development of intelligent monolith as chromatographic stationary phase during recent years.