| 顶空进样GC-SIM-MS测定硝唑尼特中溶剂残留甲醇含量 |
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| 引用本文： | 吴清盛,茅小燕,孙丽东.顶空进样GC-SIM-MS测定硝唑尼特中溶剂残留甲醇含量[J].分析测试技术与仪器,2016(2):120-123. |
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| 作者姓名： | 吴清盛 茅小燕 孙丽东 |
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| 作者单位： | 浙江育英职业技术学院,浙江 杭州,310018 |
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| 摘 要： | 利用气相色谱-选择离子监测质谱联用仪(GC-SIM-MS)测定硝唑尼特样品中溶剂残留甲醇的含量,顶空进样,温度为70℃,时间为20 min.SIM定量离子m/z 32,参考离子m/z 31,30和29.甲醇质量浓度在0.5~100μg/m L内呈良好的线性(R~2=0.999 92).方法相对标准偏差为2.49%~4.85%,样品加标回收在94.5%~102.8%之间,检测限为0.5μg/m L,符合定量分析的要求.
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| 关 键 词： | 硝唑尼特 甲醇 顶空进样 气相色谱-选择离子监测质谱联用仪 |
| 收稿时间： | 2016/2/25 0:00:00 |
| 修稿时间： | 4/8/2016 12:00:00 AM |
Determination of Methanol Solvent Residue in Nitazoxanide with Headspace GC-SIM-MS |
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| WU Qing-sheng,MAO Xiao-yan and SUN Li-dong.Determination of Methanol Solvent Residue in Nitazoxanide with Headspace GC-SIM-MS[J].Analysis and Testing Technology and Instruments,2016(2):120-123. |
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| Authors: | WU Qing-sheng MAO Xiao-yan and SUN Li-dong |
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| Institution: | Zhejiang Yuying Vocational and Technology College, Hangzhou 310018, China;Zhejiang Yuying Vocational and Technology College, Hangzhou 310018, China;Zhejiang Yuying Vocational and Technology College, Hangzhou 310018, China |
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| Abstract: | The determination of methanol solvent residues in the samples of nitazoxanide using gas chromatography-selected ion monitoring-mass spectrometry( GC-SIM-MS) has been curried out. A peak area standard curve method is used as the quantitative method. The heating temperature of the sample was 70 ℃,with an equilibrium time of 20 min, SIM m/z 32, m/z 31, 30, and 29. The concentration of toluene was linear in the range of 0. 5~100 μg /mL (R2=0. 999 92). The relative standard deviation of the method was 2. 49% ~4. 85%, the recovery was between 94. 5% ~102. 8%, the detection limit was 0. 5 μg/mL, which were in accordance with the requirement of quantitative analysis. |
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| Keywords: | nitazoxanide methanol headspace GC-SIM-MS |
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