A divergent route to diversity in macromolecules |
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Authors: | Hollink Emily Simanek Eric E |
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Institution: | Department of Chemistry, Texas A&M University, College Station, 77843, USA. |
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Abstract: | reaction: see text] A synthetic route for obtaining functional group diversity in macromolecules is described. The route relies on the differential reactivity of substituted dichlorotriazines. Treatment of a triamine core with substituted dichlorotriazines cleanly yields tris(monochlorotriazines). Subsequent S(N)Ar reactions with amine nucleophiles bearing the functional group of interest yield diversity. If the substituent on the dichlorotriazine is a protected nucleophile, deprotection of the functionalized core allows for iterative reactions and the synthesis of star, dendritic, and hybrid macromolecules. |
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