| 聚乳酸接枝葡聚糖共聚物的合成及其体外降解行为的研究 |
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| 引用本文： | 蔡晴,贝建中,王身国.聚乳酸接枝葡聚糖共聚物的合成及其体外降解行为的研究[J].高分子学报,2004(5):719-725. |
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| 作者姓名： | 蔡晴 贝建中 王身国 |
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| 作者单位： | 高分子物理与化学国家重点实验室,中国科学院化学研究所,北京,100080 |
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| 基金项目： | 国家重点基础发展规划项目资助项目 ( 973计划G19990 5 43 0 5,G19990 5 43 0 6) |
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| 摘 要： | 研究了聚乳酸接枝葡聚糖梳型共聚物的合成 ,以及共聚物的结构特征、亲水性能及降解行为的表征 .结果表明由于亲水性葡萄糖单元组分的引入以及共聚物的梳型结构特征 ,聚乳酸接枝葡聚糖共聚物的亲水性明显优于相应的线型聚乳酸 ,而且降解速度也明显加快 .由于这类梳型结构的聚多糖 聚酯共聚物综合了聚多糖细胞亲和性好和聚酯生物降解速率可调节性的特点 ,因此有望成为一类优良的细胞支架材料 .
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| 关 键 词： | 生物可降解 葡聚糖 聚乳酸 梳型 组织工程 |
| 修稿时间： | 2003年8月26日 |
STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION |
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| CAI Qing,BEI Jianzhong,WANG Shenguo.STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION[J].Acta Polymerica Sinica,2004(5):719-725. |
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| Authors: | CAI Qing BEI Jianzhong WANG Shenguo |
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| Abstract: | Comb-like biodegradable polylactide-grafted dextran copolymer (Dextran-g-PLA) was synthesized in a bulk lactide polymerization reaction using dextran derivative as macroinitiator and stannous octoate as catalyst.The Dextran-g-PLA copolymers were characterized by 1H-NMR,GPC and intrinsic viscosity measurements,and their molecular architecture was confirmed as PLA segments attached to dextran backbones.Compared to pure PLA,the copolymers showed higher hydrophilicity and faster degradation rate due to the incorporation of hydrophilic glucose units and comb-like structure,which resulted in shortened PLA chain length.This Dextran-g-PLA copolymer was envisioned having good cell affinity and being a good candidate as cell scaffold materials for tissue engineering applications. |
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| Keywords: | Biodegradable Dextran L-Lactide Brush-like Tissue engineering |
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