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A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes |
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| Authors: | Li Guolin Mehta Ricky Srikrishnan Thamarapu Nurco Daniel J Tabaczynski Walter A Alderfer James L Smith Kevin M Dougherty Thomas J Pandey Ravindra K |
| Affiliation: | Roswell Park Cancer Institute, Buffalo, NY 14263, USA. |
| Abstract: | Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH3)3SiCN-Cu(OTf)2 produced unexpected 10(3)-trimethylsiloxyl and 10(3)-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 10(3)-position of the exocyclic benzene ring to form a novel benzochlorin. |
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