| 微量元素铁与蛋白质酪氨酸硝化 |
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| 引用本文： | 李海玲,徐辉碧,高中洪. 微量元素铁与蛋白质酪氨酸硝化[J]. 化学进展, 2006, 18(5): 622-626 |
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| 作者姓名： | 李海玲 徐辉碧 高中洪 |
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| 作者单位： | 华中科技大学化学系,武汉,430074;华中科技大学化学系,武汉,430074;华中科技大学化学系,武汉,430074 |
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| 摘 要： | 蛋白质酪氨酸硝化是一氧化氮依赖的氧化应激的生物标志。蛋白质硝化将会直接影响蛋白质的催化活性、细胞信号传递和细胞骨架结构，导致相关病症的发生发展。本文介绍了铁在不同酪氨酸硝化途径中的作用，结果提示体内的微量铁对蛋白质硝化起着重要作用。
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| 关 键 词： | 铁 蛋白质酪氨酸硝化 一氧化氮 氧化应激 |
| 文章编号： | 1005-281X（2006）05-0622-05 |
| 收稿时间： | 2005-05-01 |
| 修稿时间： | 2005-08-01 |
Biological Microelement Iron and Protein Tyrosine Nitration |
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| Li Hailing,Xu Huibi,Gao Zhonghong. Biological Microelement Iron and Protein Tyrosine Nitration[J]. Progress in Chemistry, 2006, 18(5): 622-626 |
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| Authors: | Li Hailing Xu Huibi Gao Zhonghong |
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| Affiliation: | Department of Chemistry, Huazhong University of Science & TechnologyDepartment of Chemistry, Huazhong University of Science & TechnologyDepartment of Chemistry, Huazhong University of Science & Technology |
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| Abstract: | biomarker of NO-dependent oxidative stress. Protein nitration will induce the changes of protein catalytic activities, cell signaling and cell skeletal structure, and lead to relevant pathological events. In this paper, the roles of iron in different pathways of protein nitration are introduced, and the results indicated that microelement iron in vivo plays an important role in protein nitration. |
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| Keywords: | iron protein tyrosine nitration nitric oxide oxidative stress |
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