| 高效液相色谱-电喷雾串联四极杆质谱法研究人尿中毛果芸香碱代谢产物 |
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| 引用本文： | 王玲,王英武,陈刚,袁宏明. 高效液相色谱-电喷雾串联四极杆质谱法研究人尿中毛果芸香碱代谢产物[J]. 高等学校化学学报, 2005, 26(12): 2230-2232 |
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| 作者姓名： | 王玲 王英武 陈刚 袁宏明 |
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| 作者单位： | 1.吉林大学测试科学实验中心;2.生命科学学院药物代谢研究中心；3.化学学院,长春130023 |
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| 摘 要： | 本文采用高效液相色谱-电喷雾串联四极杆质谱法对人口服毛果芸香碱后的尿样的代谢产物进行了研究.
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| 关 键 词： | 毛果芸香碱 代谢物 液相色谱-串联质谱法,毛果芸香碱,代谢物,液相色谱-串联质谱法, |
| 文章编号： | 0251-0790（2005）12-2230-03 |
| 收稿时间： | 2005-05-20 |
| 修稿时间： | 2005-05-20 |
Studies on Metabolites of Pilocarpine in Human Urine Using High-performance Liquid Chromatography with Tandem Mass Spectrometry |
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| WANG Ling,WANG Ying-Wu,CHEN Gang,YUAN Hong-Ming. Studies on Metabolites of Pilocarpine in Human Urine Using High-performance Liquid Chromatography with Tandem Mass Spectrometry[J]. Chemical Research In Chinese Universities, 2005, 26(12): 2230-2232 |
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| Authors: | WANG Ling WANG Ying-Wu CHEN Gang YUAN Hong-Ming |
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| Affiliation: | 1.Analysis Test & Experiment Center;2.Research Center for Drug Metabolism,College of Life Science; 3.College of Chemistry,Jilin University,Changchun 130023,China |
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| Abstract: | Metabolism of pilocarpine in human urine was studied by high-performance liquid chromatography with tandem mass spectrometric method after single oral dose 10 mg pilocarpine hydrochloride to a healthy male volunteer. The urine sample was collected from 0 to 8 h after oral administration. The urine sample was prepared by solid phase extraction, and then was analyzed using high-performance liquid chromatography coupled with a triple quadrupole tandem mass spectrometer in multiple reaction monitoring and product ion scan mode. Three metabolites were identified as the oxidative metabolite, pilocarpic acid and the glucuronide of pilocarpine. |
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| Keywords: | Pilocarpine Metabolite Liquid chromatography-tandem mass spectrometry |
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