Fluoride-induced coupling of perfluoroketene dithioacetals with silyl alkynes: A way towards new polyfunctionalized trifluoromethyl building blocks |
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| Authors: | Tiziano Nocentini Sonia Gouault-Bironneau |
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| Affiliation: | Laboratoire Réactions Sélectives et Applications, UMR 6519 CNRS, Université de Reims Champagne-Ardenne, Faculté des Sciences, BP 1039, 51687 Reims Cedex 2, France |
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| Abstract: | Under fluoride activation, the vinyl fluorine of perfluoroketene dithioacetal may be substituted by silylated nucleophiles. Using silyl alkynes, a formal transition metal free sila-Sonogashira cross-coupling reaction occurred. The resulting enynes were hydrolyzed giving new polyfunctional trifluoromethyl building blocks. |
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| Keywords: | Ketene dithioacetal Cross-coupling Sila-Sonogashira Fluorine substitution Silyl alkynes Trifluoromethyl building blocks |
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