A new approach to fluorinated 4(3H)-quinazolinones |
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| Authors: | Anastacia A. Layeva Galina N. Lipunova Valerii N. Charushin |
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| Affiliation: | a Ural State Technical University, 19 Mira Str., 620002 Ekaterinburg, Russian Federation
b I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, 22 S. Kovalevskoy Str., 620219 Ekaterinburg, Russian Federation |
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| Abstract: | A new approach for the synthesis of fluorinated 1H-quinazolin-4-ones and 4-substituted quinazolines has been developed. 6-Fluoro-1H-quinazolin-4-ones were obtained by intramolecular cyclization of fluorine-containing S-ethyl N-benzoylisothioureas. Nucleophilic substitution reactions at positions 2 and 7, as well as alkylation at 1-position of quinazolinones were investigated. In addition, the synthesis of fluorine-containing 4-aminoquinazolines was carried out. |
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| Keywords: | Fluorine-containing quinazolinones Intramolecular cyclization Nucleophilic substitution S-Ethyl N-benzoylisothioureas |
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