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Functional tetrahydroquinoxalines from perfluoroaromatic precursors |
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| Authors: | Graham Sandford Andrzej Tadeusiak Judith AK Howard |
| Institution: | a Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK b Chemical Crystallography Group, Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK |
| Abstract: | A short series of bromo- and nitro-polyfluorobenzene derivatives gave the corresponding tetrahydroquinoxaline systems upon reaction with N,N′-dimethylethylene diamine. This annelation strategy gives useful quantities of functionalised tetrahydroquinoxaline systems which may be interesting scaffolds for the drug discovery arena. |
| Keywords: | Fluoroaromatic Nucleophilic aromatic substitution Scaffold Tetrahydroquinoxaline Bicyclic nitrogen heterocycle |
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