A novel synthesis of 5-perfluorophenyl 4,5-dihydro-1H-pyrazoles in THF or water |
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| Authors: | Wan Pang Shifa Zhu Shizheng Zhu |
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| Affiliation: | a College of Chemistry, South China University of Technology, Guangzhou 510640, China
b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China |
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| Abstract: | 5-Perfluorophenyl 4,5-dihydro-1H-pyrazoles were synthesized from 1,3-dipolar cycloaddition reaction of perfluorobenyl 2,4,6-triisopropylbenzenesulfonylhydrazone and α,β-unsaturated carbonyl compounds or acrylonitrile in THF or water. It was worthy to note that better results were obtained when water was employed as the solvent, which was considered as an effective, economic and environmentally friendly method to synthesize these pyrazole derivatives. |
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| Keywords: | Perfluorobenyl Pyrazoles α,β-Unsaturated carbonyl compounds Water |
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