Polyhalogenoheterocyclic compounds: Part 54: [1] Suzuki reactions of 2,4,6-tribromo-3,5-difluoropyridine |
| |
Authors: | Hadjar Benmansour Graham Sandford Andrei S. Batsanov |
| |
Affiliation: | a Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK b Chemical Crystallography Group, Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK |
| |
Abstract: | Palladium catalysed Suzuki cross-coupling reactions between 2,4,6-tribromo-3,5-difluoropyridine and a short series of aromatic boronic acid derivatives gave 4-bromo-3,5-difluoro-2,6-diphenylpyridine derivatives arising from displacement of bromine atoms attached to positions ortho to ring nitrogen or the corresponding triaryl systems depending on the reaction conditions. Consequently, the use of polybromofluoropyridine scaffolds for the synthesis of polyfunctional heteroaromatic derivatives is expanded further. |
| |
Keywords: | Heterocycle Heterocyclic scaffold Pyridine Fluoropyridine Suzuki Palladium catalysis |
本文献已被 ScienceDirect 等数据库收录! |
|