| 多乙酰氧基烷基(艹卓)酮和多羟基烷基(艹卓)酮的合成 |
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| 引用本文： | 尹炳柱,森章,竹下齐.多乙酰氧基烷基(艹卓)酮和多羟基烷基(艹卓)酮的合成[J].有机化学,2000,20(4). |
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| 作者姓名： | 尹炳柱 森章 竹下齐 |
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| 作者单位： | 1. 延边大学化学系,延吉,133002
2. 九州大学机能物质研究所,日本 |
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| 摘 要： | 各种溴代的烷基酚酮的乙酸酯用乙酸酐/三氟乙酸酐/乙酸(以下简称ATA)醋解可得高收率的相应的多乙酰氧基烷基酮,后者经稀酸水解几乎定量地得多羟基烷基酮。部分多乙酰氧基酮对肺癌A_(549)和上皮细胞癌显出抑制活性。
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| 关 键 词： | 多乙酰氧基烷基酮 多羟基烷基酮 醋解 ATA |
Synthesis of Polyacetoxyalkyltropones and Polyhydroxyalkyltropones |
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| YIN Bing-Zhu,AKIRA Mo-ri,Hitoshi Takeshita.Synthesis of Polyacetoxyalkyltropones and Polyhydroxyalkyltropones[J].Chinese Journal of Organic Chemistry,2000,20(4). |
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| Authors: | YIN Bing-Zhu AKIRA Mo-ri Hitoshi Takeshita |
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| Abstract: | In this paper, a series of polyacetoxyalkyltropones and polyhydroxyalkyltroponeswere synthesized by the reaction of polybromo- substituted alkyltropolones with acetyl trifuluoroacetate. The results of preliminary pharmacological test indicated that some poly - acetoxyalkyltropones had the inhibition effect against cells of KB and A549 in vitro. |
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| Keywords: | polyacetoxyalkyltropone polyhydroxyalkyltropone acetolysis ATA |
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