Synthesis of unnatural amino acids via Suzuki cross-coupling of enantiopure vinyloxazolidine derivatives |
| |
Authors: | Sabat M Johnson C R |
| |
Affiliation: | Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA. crj@chem.wayne.edu |
| |
Abstract: | [formula: see text] (R and S)-alpha-Amino alcohols and alpha-amino acids, including 4-methoxyhomophenylalanine, with a variety of unnatural side chains have been synthesized via palladium-catalyzed cross-coupling Suzuki reactions. The key building blocks 1 and 2, synthesized from the common achiral precursor 2-butene-1,4-diol, were made enantiopure utilizing a Pseudomonas cepacia lipase-catalyzed kinetic resolution. The optimal conditions for the Suzuki cross-coupling and the subsequent oxidations of the resultant alpha-amino alcohols are described. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|