| Synthesis and Crystal Structure of 2-Nitrophenyl N,N-Bis(2-chloroethyl)-N'-(4-methylbenzene- sulfonamino)ethyl-phosphorodiamidate |
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| 作者姓名： | ZHANG Gai-Hong CHEN Ru-Yu ① HUANG You MIAO Zhi-Wei |
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| 作者单位： | Institute and State Key Laboratory of Elemento-organic Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | Corresponding author. Chen Ru-Yu, born in 1919, professor, member of the Chinese Academy of Sciences, |
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| 摘 要： | 1 INTRODUCTION Nitrogen mustards (NMs) are useful chemothe- rapeutic agents in the treatment of lymphoma, leuke- mia, multiple myeloma and ovarian carcinoma1]. The antitumor activity of NMs has been attributed to their ability to cross-link the twin strands of DNA. Phosphoramide mustard is also an alkating agent that cross-links interstrand DNA, such as cyclophos- phamide (CP) , ifosfamide (IFA) and trofosf- amide2～5]. Cyclophosphamide is a widely used anticancer alklating agent …
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Synthesis and Crystal Structure of 2-Nitrophenyl N,N-Bis( 2-chloroethyl )-N'-( 4-methylbenzenesulfonamino)ethyl-phosphorodiamidate |
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| ZHANG Gai-Hong,CHEN Ru-Yu,HUANG You,MIAO Zhi-Wei.Synthesis and Crystal Structure of 2-Nitrophenyl N,N-Bis(2-chloroethyl)-N'-(4-methylbenzene- sulfonamino)ethyl-phosphorodiamidate[J].Chinese Journal of Structural Chemistry,2006,25(7). |
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| Authors: | ZHANG Gai-Hong CHEN Ru-Yu HUANG You MIAO Zhi-Wei |
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| Abstract: | The crystal structure of 2-nitrophenyl N,N-bis(2-chloroethyl)-N'-(4-methylben-zene-sulfonamino)ethyl-phosphorodiamidate (C19H25Cl2N4O6PS) was determined by single-crystal X-ray diffraction analysis. The compound crystallizes in the triclinic system, space group P1 with a = 9.3664(13), b = 9.9560(14), c = 13.1803(18) (A), α = 87.338(2), β= 87.632(2), γ = 79.536(2)°,Dc= 1.484 g/cm3, Z = 2, λ = 0.71073 (A), μ(MoKα) = 0.465, Mr = 539.36, V= 1206.7(3) (A)3, F(000)= 560, the final R = 0.0426 and wR = 0.1097 for 3463 observed reflections with 1＞ 2σ(Ⅰ). |
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| Keywords: | sulfonamide crystal structure phosphorodiamidate |
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