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N‐(2‐Hydroxypropyl)methacrylamide (HPMA) Copolymer‐Linked Nitroxides: Potential Magnetic Resonance Contrast Agents |
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| Authors: | Yuan Huang Anjan Nan Gerald M Rosen Carl S Winalski Erika Schneider Pei Tsai Hamidreza Ghandehari |
| Abstract: | N‐(2‐Hydroxypropyl)methacrylamide (HPMA) copolymer‐linked nitroxides were synthesized as macromolecular contrast agents for MR imaging. Molar relaxivities of HPMA copolymer‐linked nitroxides increased linearly in proportion to the number of nitroxides attached per gram of copolymer. HPMA copolymer‐linked nitroxides with 15, 20 and 30 mol‐% nitroxide exhibited higher relaxivities than gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA). These results demonstrate the potential of HPMA copolymer‐linked nitroxides as MR contrast agents for solid tumors.  Structure of HPMA copolymer‐linked nitroxides. |
| Keywords: | biological applications of polymers drug delivery systems HPMA copolymers magnetic resonance imaging nitroxide contrast agents |