| Abstract: | The structural elucidation of complex materials by NMR is complicated by the common occurrence of nearly coincident resonances. Congested regions necessitate increased spectral resolution, with additional time increments needed for 2D NMR spectroscopy, resulting in longer acquisition times. These demands conflict with the ever‐increasing demands for instrument time and with long‐term sample stability. Selective spectroscopy addresses both of these problems. By focusing attention only on the region of interest, fewer increments are needed. Shorter acquisitions are obtained, with a higher information content. Alternatively, the spectroscopist may choose to use these time savings to collect additional transients, allowing the study of smaller amounts of material, or low‐level impurities/isomers. Using a carbohydrate as our example, we illustrate the utility of this methodology using selHMQC, selHMBC (IMPRESS) and selHMQCTOCSY. We have found this methodology useful in the coupling of efficiency and productivity of NMR spectroscopy. Copyright © 2002 John Wiley & Sons, Ltd. |
