Synthesis and 15N NMR characterization of 4‐vinylbenzyl substituted bases of nucleic acids |
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| Authors: | Milo&#x; Sedlk Petr &#x;imnek Markus Antonietti |
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| Institution: | Miloš Sedlák,Petr Šimůnek,Markus Antonietti |
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| Abstract: | The following substances have been synthesized and characterized as monomers or intermediates for syntheses of new polymers: 1‐(4‐vinylbenzyl)uracil ( 1a ), 1‐(4‐vinylbenzyl)thymine ( 1b ), N‐4‐acetyl‐1‐(4‐vinylbenzyl)cytosine ( 1c ), 1‐(4‐vinylbenzyl)cytosine ( 1d ), 9‐(4‐vinylbenzyl)adenine ( 2a ), 2‐amino‐9‐(4‐vinylbenzyl)‐6‐chloro‐9H‐purine ( 2b ), and 9‐(4‐vinylbenzyl)‐guanine ( 2c ). The alkylation reactions with 4‐vinylbenzyl chloride were catalyzed with anhydrous sodium iodide. The substitution at position 9 in substances 2a‐c was confirmed by 15N NMR. |
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