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Reactions of Polymer‐Supported α‐Selenoaldehydes with Grignard Regents. A Facile Solid‐Phase Stereoselective Synthesis of (E)‐1,2‐Disubstituted Ethenes |
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| Authors: | Shou‐Ri Sheng Xian Huang |
| Abstract: | Polymer‐supported α‐selenoaldehydes easily obtained by reaction of polymer‐supported 4‐(phenylseleno)morpholine with aldehydes react with Grignard reagents to form polymer‐supported β‐hydroxyalkyl selenides, which were treated with thionyl chloride/triethylamine leading to (E)‐1,2‐disubstituted ethenes in good yields. |
| Keywords: | Solid‐phase organic synthesis Polymer‐supported (4‐phenylseleno)morpholine Polymer‐supported α ‐selenoaldehyde (E)‐1 2‐Disubstituted ethene |