| 超高效液相色谱-电喷雾离子源-串联三重四极杆质谱分析人血中羟基多溴联苯醚 |
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| 引用本文： | 王英,丁问微,金军.超高效液相色谱-电喷雾离子源-串联三重四极杆质谱分析人血中羟基多溴联苯醚[J].分析化学,2011,39(1):22-26. |
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| 作者姓名： | 王英 丁问微 金军 |
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| 作者单位： | 中央民族大学生命与环境科学学院; |
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| 基金项目： | 高等学校学科创新引智计划“B08044”; 国家自然科学基金(No.20507023); 北京高等学校化学实验教学示范中心建设项目(2008)资助 |
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| 摘 要： | 建立了超高效液相色谱-电喷雾离子源串联三重四极杆质谱(UPLC-ESI-MS-MS)在负离子模式下测定人血中5种羟基多溴联苯醚(HO-PBDEs)的方法.血清样品中加入替代内标13C<,12四溴双酚-A(13C<,12TBBP-A),经萃取、净化、浓缩等预处理过程,多重反应监测(MRM),扫描通道为:m/z 555→4...
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| 关 键 词： | 超高效液相色谱-三重四极杆质谱 人血 羟基多溴联苯醚 |
Determination of Hydroxylated Polylrominated Diphenyl Ethers in Human Serum by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry |
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| WANG Ying,DING Wen-Wei,JIN Jun.Determination of Hydroxylated Polylrominated Diphenyl Ethers in Human Serum by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2011,39(1):22-26. |
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| Authors: | WANG Ying DING Wen-Wei JIN Jun |
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| Institution: | WANG Ying,DING Wen-Wei,JIN Jun*(Minzu University of China,College of Life and Environmental Science,Beijing 100081) |
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| Abstract: | A new method has been developed for the simultaneous analysis of five hydroxylated polybrominated diphenyl ethers(HO-PBDEs) in human serum using ultra performance liquid chromatography-electrospray ion source tandem mass spectrometry(UPLC-ESI-MS-MS) in negative ion mode.The serum samples were spiked with 13C12 Tetrabromobisphenol-A(TBBP-A) as surrogate internal standard before extracting,then the samples were further cleaned up and concentrated.Detection was performed by multiple reaction monitoring(MRM) mo... |
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| Keywords: | Ultra performance liquid chromatography-electrospray ion source tandem mass spectrometry Human serum Hydroxylated polybrominated diphenyl ethers |
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