A racemic synthesis of an AB-ring system of hexacyclinic acid |
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| Authors: | Clarke Paul A Cridland Andrew P |
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| Affiliation: | School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom. paul.clarke@nottingham.ac.uk |
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| Abstract: | [structure: see text] An AB-ring system of the polyketide natural product hexacyclinic acid has been synthesized in racemic form. The key steps were an intramolecular Diels-Alder cyclization of an ester tethered 1,3-nonadiene-8-yne, which generated the B-ring, and a samarium diiodide mediated reductive annulation, which was used to form the A-ring. |
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