Aziridines in one step from hydantoins via Red-Al mediated ring-contraction |
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| Authors: | Fredrik von Kieseritzky,Johan Lindströ m |
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| Affiliation: | a Medicinal Chemistry, CSNP iMed, AstraZeneca R&D Södertälje, 151 85 Södertälje, Sweden |
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| Abstract: | We have developed a new method to synthesize aziridines from their corresponding hydantoins in one step using an excess of Red-Al overnight in refluxing toluene. This allows direct access to N-H aziridines without the need for protecting group strategies. |
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| Keywords: | Aziridines Hydantoins Ring-contraction Reduction Red-Al |
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