Syntheses of chiral oxazolo[2,3-a]tetrahydroisoquinoline and its asymmetric alkylation. Synthesis of (S)-(−)- and (R)-(+)-sa1solidines |
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| Authors: | Masatoshi Yamato Kuniko Hashigaki Shigetaka Ishikawa Nazmul Qais |
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| Affiliation: | Faculty of Pharmaceutical Sciences, University of Okayama Tsushima-naka, Okayama 700, Japan |
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| Abstract: | The isoquinolinium bromide (4), on treatment with base, underwent cyclization to give the chiral oxazolotetrahydroisoquinoline (5) with a high diastereoselectivity, which was converted to optically pure salsolidine. |
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